An Investigation of the Shortcomings of the CONSORT 2010 Statement for the Reporting of Group Sequential Randomised Controlled Trials: A Methodological Systematic Review.
BACKGROUND:It can be argued that adaptive designs are underused in clinical research.We have explored concerns related to inadequate reporting of such trials, which may influence their uptake.Through a careful examination of the literature, we evaluated the standards of reporting of group sequential (GS) randomised controlled trials, one form of a